Publications

2020

77. Cui, Z.; Overbay, J.; Wang, X.; Liu, X.; Zhang, Y.; Bhardwaj, M.; Lemke, A.; Wiegmann, D.; Niro, G.; Thorson, J. S.; Ducho, C.; & Van Lanen, S. G. (2020) Pyridoxal-5’-phosphate-dependent alkyl transfer in nucleoside antibiotic biosynthesis. Nat. Chem. Biol., in press.

       Highlight: Awakawa T: Faculty Opinions Recommendation of [Cui Z et al., Nat Chem Biol 2020]. In Faculty Opinions, 06 Jul 2020; 10.3410/f.738064201.793575801

76. Zhang, Y.; Zhang, J. Ponomareva, L.; Cui, Z.; Van Lanen, S. G.; & Thorson, J. (2020) Sugar-pirating as an enabling platform for the synthesis of 4,6-dideoxyhexoses. J. Am. Chem. Soc., doi.org/10.1021/jacs.9b13766.

75. Clinger, J. A.; Wang, X.; Cai, W.; Zhu, Y.; Miller, M. D.; Zhan, C.-G.; Van Lanen, S. G.; Thorson, J. S.; Phillips, G. N. (2020) The crystal structure of AbsH3: A putative FAD-dependent reductase in the abyssomicin biosynthesis pathway. Proteins: Structure, Function, and Bioinformatics, in press.

2019

75. Gust, B., Liu, X., Cai, W., Goswami, A., & Van Lanen, S. G., (2018) Biosynthesis of nucleoside antibiotics: characterization of gene clusters and functional and mechanistic insight of key enzymes. Nat. Prod. Rep., submitted.

74. Wang, X.; Elshahawi, S.; Ponomareva, L.; Ye, Q.; Copley, G.; Liu, Y.; Hower, J.; Hatcher, B.; Kharel, M.; Van Lanen, S. G.; She, Q.-B.; Voss, S. R.; Thorson, J. S.; Shaaban, K. (2019) Isolation, structure determination and functional characterization of nybomycin analogues produced by an underground coal mine acid drainage Streptomyces. J. Nat. Prod., 82, 3469-3476.

73. Michailidou, F., Burnett, D., Vishnuprasadji Sharma, S., Van Lanen, S. G., Goss, R. J. M. (2019) Natural products incorporating pyrimidine nucleosides and their modified analogues. Comprehensive Natural Products III. Chemistry and Biology, Ed. Liu, H.-W. and Begley, T. P.

72. Pandey, A.; Savino, C.; Ahn, S. H. Yang, Z.; Van Lanen, S. G.; Boros, E. (2019) A theranostic gallium siderophore ciprofloxacin conjugate with broad spectrum antibiotic potency. J. Med. Chem., 62, 9947-9960.

71. Zhang, Y.; Ye, Q.; Pnomareva, L. V.; Cao, Y.; Liu, Y.; Cui, Z.; Van Lanen, S. G.; Voss, S. R.; She, Q.-B.; Thorson, J. S. (2019) Total synthesis of griseusins and elucidation of the griseusin mechanism of action. Chem. Sci., 10, 7641-7648.

70. Wang, X., Abbas, M., Zhang, Y., Elshahawi, S., Ponomareva, L., Cui, Z., Van Lanen, S. G., Sajid, I., Voss, S. R., Shaaban, K., & Thorson, J. (2019) Baraphenazines A-G, divergent fused phenazine-based metabolites from a Himalayan Streptomyces. J. Nat. Prod., 82, 1686-1693.

69. McErlean, M., Overbay, J., & Van Lanen, S. G. (2019) Refining and expanding nonribosomal peptide synthetase function and mechanism. J. Ind. Microbiol. Biotechnol., 46, 493-513.

68. Biecker, A., Liu, X., Thorson, J., Yang, Z., & Van Lanen, S. G. (2019) Biosynthesis and synthetic strategies for assembling capuramycin-type antituberculosis antibiotics. Molecules, 24, 433.

67. Zhang, B., Kopper, T., Liu, X., Cui, Z., Van Lanen, S. G., Gensel, J. (2019) Macrolide derivatives reduce pro-inflammatory macrophage activation and macrophage-mediated neurotoxicity. CNS Neurosci. Ther. 25, 591-600.

2018

66. Ying, H., Liu, X., Cui, Z., Wiegmann, D., Niro, G., Ducho, C., Song, Y., Yang, Z., & Van Lanen, S. G. (2018) Pyridoxal-5’-phosphate as an oxygenase cofactor: Discovery of a carboxamide-forming, α-amino acid monooxygenase-decarboxylase. Proc. Natl. Acad. Sci. USA, 115, 974-979.

       Highlight: Tang G: Faculty Opinions Recommendation of [Huang Y et al., Proc Natl Acad Sci USA 2018 115(5):974-979]. In Faculty Opinions, 16 Feb 2018; 10.3410/f.732523101.793542567

65. Cui, Z., Liu, X., Overbay, J., Cai, W., Wang, X., Wiegmann, D., Niro, G., Thorson, J. S., Ducho, C., & Van Lanen, S. G. (2018) Enzymatic synthesis of the ribosylated glycyl-uridine disaccharide core of peptidyl nucleoside antibiotics. J. Org. Chem. 83, 7239-7249.

64. Cui, Z., Wang, X. C., Liu, X., Lemke, A., Koppermann, S., Ducho, C., Rohr. J., Thorson, J. S., & Van Lanen, S. G. (2018) Self-resistance during muraymycin biosynthesis: A complementary nucleotidyltransferase and phosphotransferase with identical modification sites and distinct termporal order. Antimicrob. Agents Chemother. 62, e00193-18.

63. Cui, Z., Wang, X., Koppermann, S., Thorson, J. S., Ducho, C., & Van Lanen, S. G. (2018) Antibacterial muraymycins from mutant strains of Streptomyces sp. NRRL 30471. J. Nat. Prod. 81, 942-948.

62. Koppermann, S., Cui, Z., Fisher, P. D., Wang, X., Ludwig, J., Thorson, J. S., Van Lanen, S. G., Ducho, C. (2018) Insights into the target Interaction of naturally occurring muraymycin nucleoside antibiotics. ChemMedChem, 13, 779-784.

2017

61. Van Lanen, S. G. (2017) SAM cycles up for colibactin, Nat. Chem. Biol. 13, 1059-1060.

60. Jin, Y., Fan, S., Lv, G., Meng, H., Sun, Z., Jiang, W., Van Lanen, S. G., Yang, Z. (2017) Computer-aided drug design of capuramycin analogues as anti-tuberculosis antibiotics by 3D-QSAR and molecular docking. Open Chem., 15:1-9.

59. Wang, X. Elshahawi, S. I., Cai, W., Zhang, Y., Ponomareva, L. V. Chen, X., Copley, G. C., Hower, J. C., Zhan, C.-G., Parkin, S., Van Lanen, S. G., Shaaban, K. A., & Thorson, J. S. (2017) Unique bi- and tetracyclic spirotetronates from the coal mine fire isolate Streptomyces sp. LC-6-2, J. Nat. Prod. 80, 1141-1149.

58. Goswami, A., Liu, X., Cai, W., Wyche, T. P., Bugni, T. S., Meurillon, M., Peyrottes, S., Perigaud, C., Nonaka, K., Rohr, J., & Van Lanen, S. G. (2017) Non-heme Fe(II), a-ketoglutarate:UMP dioxygenases LipL and Cpr19 catalyzed oxidative dephosphorylation of UMP by stereospecific hydroxylation, FEBS Lett. 591, 468-478.

57. Chen, S., Van Lanen, S. G., & Kinney, W. A. (2017) Nature’s combinatorial biosynthesis and engineered production of nucleoside antibiotics in Streptomyces. World J. Microbiol. Biotechnol., 33, 66.

2016

56. Cai, W., Wang, X., Elshahawi, S., Ponomareva, L., Liu, X., McErlean, M., Zheng, C., Arlinghaus, A., Thorson, J., & Van Lanen, S. G. (2016) Antibacterial and cytotoxic actinomycins Y6-Y9 and Zp from Streptomyces sp. strain Gö-GS12. J. Nat. Prod., 79, 2731-2739.

55. Huber, T. D., Wang, F., Singh, S., Johson, B. R., Zhang, J., Sunkara, M., Van Lanen, S. G., Morris, A. J., Phillips, G.N., & Thorson, J. S. (2016) Functional AdoMet isosteres resistant to classical AdoMet degradation pathways. ACS Chem. Biol. 11, 2484-2491.

54. Liu, X., Jin, Y., Cai, W., Green, K. D., Goswami, A., Garneau-Tsodikova, S., Nonaka, K., Baba, S., Funabashi, M., Yang, Z., & Van Lanen, S. G. (2016) A biocatalytic approach to capuramycin analogues by exploiting a substrate permissive N-transacylase CapW. Org. Biol. Chem., 14, 3956-3962.

53. Liu, X., Jin, Y., Cui, Z., Nonaka, K., Baba, S., Funabashi, M., Yang, Z., & Van Lanen, S. G. (2016) The role of a nonribomomal peptide synthetase in L-lysine lactamization during capuramycin biosynthesis. ChemBioChem, 17, 804-910.

52. Kuklarni, A.; Zeng, Y., Zhou, W., Van Lanen, S. G., Zhang, W.; Chen, S. (2016) A branch point of Streptomyces sulfur amino acid metabolism controls the production of albomycin, Appl. Environ. Microbiol. 82, 467-477.

2010-2015

51. Wang, X., Reynolds, A. R., Elshahawi, S. I., Saaban, K. A., Ponomareva, L. V., Saunders, M. A., Elgumati, I. S., Zhang, Y., Copley, G. C., Hower, J. C., Sunkara, M., Morris, A. J., Kharel, M. K., Van Lanen, S. G., Prendergast, M. A., & Thorson, J. S. (2015) Terfestatins B and C, new p-terphenyl glycosides produced by Streptomyces sp. RM-5-8, Org. Lett. 17, 2796-2799.

50. Cai, W., Goswami, A., Yang, Z., Liu, X., Green, K. D., Barnard-Britson, S., Baba, S., Funabashi, M., Nonaka, K., Sunkara, M., Morris, A. J., Spork, A. P., Ducho, C., Garneau-Tsodikova, S., Thorson, S., & Van Lanen, S. G. (2015) The biosynthesis of capuramycin-type antibiotics: Identification of the A-102395 biosynthetic gene cluster, mechanism of self-resistance, and formation of uridine-5′-carboxamide, J. Biol Chem. 290, 13710-13724.

49. Goswami^, A. & Van Lanen, S.G. (2015) Enzymatic strategies and biocatalysts for amide bond formation: Tricks of the trade outside of the ribosome, Molecular Biosystems, 11, 338-353.

48. Singh, S., Zhang, J., Huber, T. D., Sunkara, M., Hurley, K., Goff, R. D., Wang, G., Zhang, W., Liu, C., Rohr, J., Van Lanen, S. G., Morris, A. J., & Thorson, J. S. (2014) Facile chemoenzymatic strategies for the synthesis and utilization of S-adenosyl-l-methionine analogues, Angew. Chemie Int. Ed., 53, 3965-3969.

47. Bachmann, B. O., Van Lanen, S. G., & Baltz, D. (2014) Microbial genome mining for accelerated natural products discovery: is a renaissance in the making?, J. Ind. Microbiol. Biotechnol. 41, 175-184.

46. Funabashi, M., Baba, S., Takatsu, T., Kizuka, M., Ohata, Y., Tanaka, M., Nonaka, K., Spork, A. P., Ducho, C., Chen, W.-C. L., & Van Lanen, S. G. (2013) Structure-based gene targeting discovery of a novel bacterial translocase I inhibitor, sphaerimicin, Angew. Chemie Int. Ed., 52, 11821-11826.

45. Van Lanen, S. G. (2013) A sulfonate relay revealed, Nat. Chem. Biol., 9, 602-603.

44. Chi, X., Nonaka, K., Tibrewal, N., Baba, S., Funabashi, M., & Van Lanen, S. G. (2013) The muraminomicin biosynthetic gene cluster and enzymatic formation of the 2-deoxyaminoribosyl appendage, Med. Chem. Commun., 4, 239-243 (invited manuscript for a New Talent special edition).

43. Barnard-Britson, S., Chi, X., Nonaka, K., Spork, A., Tibrewal, N., Goswami, A., Pahari, P., Ducho, C., Rohr, J., & Van Lanen, S. G. (2012) Amalgamation of nucleosides and amino acids in antibiotic biosynthesis: Discovery of an l-threonine:uridine-5’-aldehyde transaldolase, J. Am. Chem. Soc.134, 18514-18517.

42. Wang, G., Pahari, P., Kharel, M. K., Chen, J., Zhu, H., Van Lanen, S. G., & Rohr, J. (2012) Two bifunctional enzymes cooperate in the biosynthesis and the attachment of deoxysugars of the antitumor antibiotic mithramycin, Angew. Chem. Int. Ed. 51, 10638-10642.

41. Tibrewal, N., Downey, T. E., Van Lanen, S. G., Sharif, E. U., O’Doherty, G., & Rohr, J. (2012) Roles of the synergistic reductive O-methyltransferase GilM and of O-methyltransferase GilMT in the gilvocarcin biosynthetic pathway, J. Am. Chem. Soc., 134, 12402-12405.

40. Zeng, Y., Kulkami, A., Yang, Z., Patil, P. B., Zhou, W., Chi, X., Van Lanen, S. G., & Chen, S. (2012) Biosynthesis of albomycin d2 provides a template for assembling siderophore and aminoacyl-tRNA synthetase inhibitor conjugates, ACS Chem. Biol. 7, 1565-1575.

39. Yang, Z., Unrine, J., Nonaka, K., & Van Lanen, S. G. (2012) Fe(II)-dependent, uridine-5’-monophosphate:a-ketoglutarate dioxygenases in the synthesis of 5’-modified nucleosides, Methods Enzymol. 516, 153-168.

38. Pahari, P., Kharel, M. K., Shephard, M. D., Van Lanen, S. G., & Rohr J. (2012) Enzymatic total synthesis of defucogilvocarcin M and its implications for gilvocarcin biosynthesis, Angew. Chem. Int. Ed., 51, 1216-1220.

37. Chi, X., Pahari, P., Nonaka, K., & Van Lanen, S. G. (2011) Biosynthetic origin and mechanism of formation of the aminoribosyl moiety of peptidyl nucleoside antibiotics, J. Am. Chem. Soc. ,133, 14452-14459.

36. Koryakina I., Neville J, Nonaka, K., Van Lanen S. G., & Williams G. J. (2011) A high-throughput screen for directed evolution of a natural product sulfotransferase. J. Biomol. Screen., 16, 845-851.

35. Yang Z., Chi X., Funabashi, M., Baba S., Nonaka K., Pahari, P., Unrine J., Jacobson J., Elliott G.I., Rohr, J., & Van Lanen, S. G. (2011) Characterization of LipL as a non-heme, Fe(II)-dependent a-ketoglutarate:UMP dioxygenase that generates uridine-5’-aldehyde during A-90289 biosynthesis. J. Biol. Chem., 286, 7885-7892.

34. Van Lanen, S. G. & Shen, B. (2011) Combinatorial biosynthesis of anticancer natural products. In Anticancer Agents from Natural Products, eds. G. M. Cragg, D. G. I. Kingston, D. J. Newmann, 2^nd ed, pp 671-698.

33. Shepherd M. D., Kharel M. K., Zhu, L. L., Van Lanen, S. G., & Rohr, J. (2010) Delineating the earliest steps of gilvocarcin biosynthesis: role of GilP and GilQ in starter unit specificity. Org. Biomol. Chem., 8, 3851-3856.

32. Funabashi, M., Yang, Z., Nonaka, K., Hosobuchi, M., Fujita, Y., Shibata, T., Chi, X. & Van Lanen, S. G. (2010) An ATP-independent strategy for amide bond formation in antibiotic biosynthesis. Nat. Chem. Biol., 6, 581-586.

      Highlighted in:      

1. Faculty of 1000 Biology (Post-publication peer-review by experts). Evaluations placed this publication in the top 2% of published articles in biology and medicine as of Feb. 7, 2011. http://f1000biology.com/article/id/3765961/evaluation

         i.  Yi Tang, UCLA, Jul 2010

         ii.  Squire Booker, Penn State University, Jan 2011

         iii.  Donald Pinto,  Bristol-Myers Squibb, Feb 2011

• Chemical & Engineering News, Latest News, June 30, 2010. http://pubs.acs.org/cen/news/88/i27/8827news4.html
• SciBX: Science-Business eXchange

31.  Moon, M. & Van Lanen, S. G. (2010) Characterization of a dual specificity adenylation enzyme with dual function in nikkomycin biosynthesis. Biopolymers, 93, 791-801.

30.  Yang, Z., Funabashi, M., Nonaka, K., Hosobuchi, M., Shibata, T., Pahari, P., & Van Lanen, S. G. (2010) Functional and kinetic analysis of the phosphotransferase CapP conferring selective self-resistance to capuramycin antibiotics, J. Biol. Chem. 285, 12899-12905.

29. Funabashi, M. Baba, S., Nonaka, K., Hosobuchi, M., Fujita, Y., Shibata, T., & Van Lanen, S. G. (2010) The biosynthesis of liposidomycin-like A-90289 antibiotics featuring a new type of sulfotransferase. ChemBioChem, 11, 184-190.

2000-2009

28. Van Lanen, S. G., Lin, S., Horsman, G. P., Shen, B. (2009) Characterization of SgcE6, the flavin reductase component supporting FAD-dependent halogenation and hydroxylation in the biosynthesis of the enediyne antitumor antibiotic C-1027. FEMS Microbiol. Lett. 300, 237-241.

27. Nonaka, K., Funabashi, M., Yada, C., Hosobuchi, M., Masuda, N., Shibata, T., & Van Lanen, S. G. (2009) Identification of the biosynthetic gene cluster of A-500359s in Streptomyces griseus SANK60196. J. Antibiot., 62, 325-332.

26. Lin, S., Van Lanen, S. G., & Shen, B. (2009) A free-standing condensation enzyme catalyzing ester bond formation in C-1027 biosynthesis. Proc. Natl. Acad. Sci. U.S.A., 106, 4183-4188.

25. Horsman, G. P., Van Lanen, S. G., & Shen, B. (2009) Iterative type I polyketide synthases for enediyne core biosynthesis. Methods in Enzymol., 459, 97-112.

24. Jiang, H., Zirkle, R., Metz, J. G., Braun, L., Richter, L., Van Lanen, S. G., & Shen, B. (2008) The role of tandem acyl carrier protein domains in polyunsaturated fatty acid biosynthesis. J. Am. Chem. Soc. 130, 6336-6337.

23. Van Lanen, S. G., & Shen, B. (2008) Advances in polyketide synthase structure and mechanism. Curr. Opin. Drug Discov. Develop., 11, 186-195.

22. Van Lanen, S. G., & Shen, B. (2008) Biosynthesis of enediyne antitumor antibiotics. Curr. Top. Med. Chem., 8, 448-459.

21. Lin, S., Van Lanen, S. G., & Shen, B. (2008) Characterization of the two-component, FAD-dependent monooxygenase SgcC that requires carrier protein-tethered substrates for the biosynthesis of the enediyne antitumor antibiotic C-1027. J. Am. Chem. Soc. 130, 6616-6623.

20. Zhang, J.*; Van Lanen, S. G.*, Ju, J., Liu, W., Dorrestein, P. C., Li, W., Kelleher, N. L., & Shen, B. (2008) A phosphopantetheinylating polyketide synthase producing a linear polyene to initiate the biosynthesis of the enediyne antitumor antibiotics. Proc. Natl. Acad. Sci. U.S.A. 105, 1460-1465. *contributed equally to this work

19. Van Lanen, S. G., Lin, S., & Shen, B. (2008) The biosynthesis of the enediyne antitumor antibiotic C-1027 involves a new branching point in chorismate metabolism. Proc. Natl. Acad. Sci. U.S.A.,105, 494-499.

18. Lee, B. W. K., Van Lanen, S. G., & Iwata-Reuyl, D. (2007) Mechanistic studies of Bacillus subtilis  QueF, the nitrile oxidoreductase involved in queuosine biosynthesis. Biochemistry 46, 12844-12854.

17. Van Lanen, S. G., Oh, T., Liu, W., Wendt-Pienkowski, E., & Shen, B. (2007) Characterization of the gene cluster for maduropeptin from Actinomadura  madurae ATCC 39144 supporting a unifying paradigm for enediyne biosynthesis. J. Am. Chem. Soc. 129, 13082-13094.

16. Lin, S., Van Lanen, S. G., & Shen, B. (2007) Regioselective chlorination of (S)-b-tyrosine-S-carrier protein    catalyzed by SgcC3 in the biosynthesis of the enediyne antitumor antibiotic C-1027. J. Am. Chem.Soc. 129, 12432-12438.

15. Christianson, C. V., Montavon, T. J., Van Lanen, S. G., Shen, B., & Bruner, S. D. (2007) The structure of L-tyrosine 2,3-aminomutase from the C-1027 enediyne antitumor antibiotic biosynthetic pathway. Biochemistry 46, 7205-7214.

14. Cooke, H. A., Zhang, J., Griffin, M. A., Nonaka, K., Van Lanen, S. G., Shen, B., & Bruner, S. D. (2007) Characterization of NcsB2 as a promiscuous naphthoic acid/coenzyme A ligase integral to the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin. J. Am. Chem. Soc. 129, 7728-7729.

13. Van Lanen, S. G., & Shen, B. (2006) Progress of combinatorial biosynthesis for drug discovery. Drug Disc. Today: Technologies 3, 285-292.

12. Van Lanen, S. G., Lin, S., Dorrestein, P. C., Kelleher, N. L., & Shen, B. (2006) Substrate specificity of the adenylation enzyme SgcC1 involved in the biosynthesis of the enediyne antitumor antibiotic C-1027. J. Biol. Chem. 281, 29633-29640.

11. Dorrestein, P. C., Van Lanen, S. G., Li, W., Zhao, C., Deng, Z., Shen, B., & Kelleher, N. L. (2006) The Bifunctional glyceryl transferase/phosphatase OzmB belonging to the HAD superfamily that diverts 1,3-bisphosphoglycerate into polyketide biosynthesis. J. Am. Chem. Soc. 128, 10386-10387.

10. Van Lanen, S. G., & Shen, B. (2006) Microbial genomics for the improvement of natural product discovery. Curr. Opin. Microbiol. 9, 252-260.

9.  Shen, B.; Cheng, Y.-Q.; Christenson, S. D.; Jiang, H.; Ju, J.; Kwon, H.-J.; Lim, S.-K.; Liu, W.; Nonaka, K.; Seo, J.-W.; Smith, W. C.; Stabdage, S.; Tang, G.-L.; Van Lanen, S. G.; Zhang, J. (2006) Polyketide biosynthesis beyond the type I, II, and III polyketide synthase paradigms: a progress report. In Polyketides: Biosynthesis, Biological Activity, and Genetic Engineering. Eds A. M. Rimando and S. R. Bearson, ACS Symposium Series 955.

8.  Van Lanen, S. G., Reader, J., Swairjo, M. A., de Crécy-Lagard, V., Lee, B., & Iwata-Reuyl, D. (2005). From cyclohydrolase to oxidoreductase: Discovery of nitrile reductase activity in a common fold. Proc. Nat. Acad. Sci. U.S.A. 102, 4264-4269.

7.  Van Lanen, S. G., Dorrestein, P. C., Christenson, S. D. Liu, W., Ju, J., Kelleher, N. L., & Shen, B. (2005) Biosynthesis of the b-amino acid moiety of the enediyne antitumor antibiotic C-1027 featuring b-amino acyl-S-carrier protein intermediates. J. Am. Chem. Soc. 127, 11594-11595.

6.  Liu, W., Nonaka, K., Nie, L., Zhang, J., Christenson, S. D., Bae, J., Van Lanen, S. G., Zazopoulos, E., Farnet, C. M., Yang, C. F. & Shen, B. (2005) The neocarzinostatin biosynthetic gene cluster from Streptomyces carzinostaticus ATCC 15944 involving two iterative type I polyketide synthases. Chem. Biol. 12, 293-302.

5.  Galm, U., Hager, M. H., Van Lanen, S. G., Ju, J., Thorson, J. S., & Shen, B. (2005) Antitumor antibiotics: bleomycin, enediynes, and mitomycin. Chem. Rev. 105, 739-758.

4.  Swairjo, M. A., Reddy, R. R., Lee, B., Van Lanen, S. G., Brown, S., de Crecy-Lagard, V., Iwata-Reuyl, D., & Schimmel, P. (2005) Crystallization and preliminary X-ray characterization of the nitrile reductase QueF: a queuosine-biosynthesis enzyme. Acta Crystallogr. Sect. F: Struct. Biol. Crystall. Comm. F61, 945-948.

3.  Van Lanen, S. G., & Iwata-Reuyl, D. (2003) Kinetic mechanism of tRNA-modifying enzyme QueA. Biochemistry 42, 5312-5320.

2.  Van Lanen, S. G., Daoud Kinzie, S., Matthieu, S., Link, T., Culp, J., & Iwata-Reuyl, D. (2003) tRNA modification by S-adenosylmethionine:tRNA ribosyltransferase-isomerase (QueA): Assay development and characterization of the recombinant enzyme. J. Biol. Chem. 278: 10491-9.

1.  Bai, Y., Fox, D. T., Lacy, J. A., Van Lanen, S. G., & Iwata-Reuyl, D. (2000) Hypermodification of tRNA in thermophilic Archaea.  Cloning, overexpression, and characterization of tRNA-guanine transglycosylase from Methanococcus jannaschii. J. Biol. Chem. 275, 28731-28738.